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In concluding that there is “no strong correlation between genotype and chemotype for THCA”, the authors appear to have overlooked the possibility that CBDA synthase rather than THCA synthase is responsible for the major chemotypic difference between drug-type and non-drug-type Cannabis. All five drug-type samples for which CBDA synthase sequences are shown in Figure 4 share a four-base (nonsense-inducing) deletion at position 153 compared to sequences encoding a functional enzyme. This finding is consistent with the main conclusion of Weiblen et al., namely in that plants lacking functional CBDA synthase produce primarily THCA [2]. We based our conclusion on the fact that THCA synthase and CBDA synthase compete for a common substrate, CBGA. Drug-type, intermediate and non-drug-type plants are widely recognized in the literature according to the ratio of THCA:CBDA [3].

Commentary on “Complex Variability within the THCA and CBDA Synthase Genes in Cannabis Species”