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Theperipheralvasodilatation causes relative underfilling ofthevascular comparfinent,whichleadto ascitesformation. A synthetic analogue of somatostatin has been shown to reduce splanchnic bloodflow. The role of splanchnic vasoconstictor in reducing peripheral vasodilatation is not yet elucidated. The aims ofthe study is to asses the rolc of splanchnic vasoconstriction onperipheralvasodilatation to decrease ascites formation. This study was a prospective, controlled, randomized on liver cirrhosis cases with ascites. Group A consisted of 7 cases were treated with spironolactone tvvo times 100 mg a day, Group B consistèd of 10 cases were treated with spironolactone tyvo times 100 mg a day plus 0,1 mg sornatostatin synthetic analogue once a day and Group C consisted of 9 patients treated with spironolactone two times 100 mg a day plus 0,1 mg somatostatin synthetic analogue three time!; a day. At the entry of the study and at the end, body weight, diuresis, biochemical test, blood electrolytes and portal bloodflow were measured. The body weight and diuresis were measured every day. The decrease ofbody weight was significant among Group C compared to Group B and Group A (p= 0.006, p= 0.523, and p= 0.079, respectively). The diuresis effect was increased significantly among Group C compared to Group B and Group A (p= 0.02A, p= 0.339, and p0.063, respectively). There were no increased of portal bloodflow. This study proved the role of peripheral vasodilatation in water retention and ascites formation in cirrhosis cases.

The role of splanchnic vasoconstrictor in decreasing peripheral vasodilatation to reduce ascites formation of liver cirrhosis