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A simple, accurate and highly sensitive spectrophotometric methods are proposed for the rapid and accurate determination of Memantine HCl (MEM) using Bromophenol blue (BPB), Bromocressol purple (BCP) and Methyl orange (MO). The developed methods involve formation of stable yellow colored chloroform extractable ion-associate complexes of the amino derivative (basic nitrogen) of the MEM with three sulphonphthalein acid dyes, namely; BPB, BCP and MO, in phthalate buffer of pH range (3.0–3.8). The ion-associates exhibit absorption maxima at 415, 410 and 422 nm for BPB, BCP and MO, respectively. MEM can be determined up to 1.1-12.5, 0.8-13.1 and 0.6-14 μg/mL, respectively. The effect of optimum conditions via pH, reagent concentration, time, and solvent were studied. The low relative standard deviation values indicate good precision and high recovery values. These methods have been successfully applied for the assay of MEM in pharmaceutical formulations. Statistical comparison of the results with the reference method shows excellent agreement and indicates no significant difference in accuracy and precision.

canadian chemical transactions

Extractive-Spectrophotometric Methods for Determination of Alzheimer’s Drug in Pharmaceutical Formulations and in Biological Samples Using Sulphonphthalein Acid Dyes