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Mulberry extracts can be incorporated into skin-whitening products. The compound attributed to lighten the skin isarbutin, a form of hydroquinone that inhibits melanin release by suppressing the tyrosinase enzyme. For the cosmeticapplications, the physiological effects of mulberry (Morus alba) extracts were investigated. The water soluble fractionof mulberry contains higher amount of protein (16.28~4.47%) in contrast to fat (1.55~1.41%). In addition, the fractionabundantly contains succinic acid (972.4-275.8 mg/g) and phosphoric acid (1,628.4-121.9 mg/g) in different parts ofmulberry. The free radical scavenging ability in water soluble fraction was found to display remarkable effects incomparison with methanol and ethyl acetate fraction. The ethyl acetate-soluble of root and leaf showed remarkabletyrosinase inhibition activity by IC 50 (µg/ml). The anticancer activity of methanol fraction obtained from mulberry usinghuman cancer cell lines showed growth inhibition effect (270.14 mg/ml in Calu-6 cells, 295.29 mg/ml in HCT-116, and332.29 mg/ml in MCF-7 cells, respectively). Based on the results, Morus alba extracts include cosmetic ingredients withantioxidizing and whitening properties.Key words

Physiological and Whitening Effects of Morus alba Extracts