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Extended spectrum beta-lactamases are modified beta-lactamase enzymes that impart resistance to third-generation cephalosporins and make all beta-lactam antibiotics and cephalosporins useless for therapy. We compared the antimicrobial susceptibility profiles of extended-spectrum beta-lactamase (ESBL)-producing and non-ESBL-producing isolates of Klebsiella pneumoniae. The ESBL producers had significantly diminished susceptibility compared with the non-ESBL producers for gentamicin (P &lt; .001), tobramycin (P &lt; .001), amikacin (P &lt; .005), trimethoprim-sulfamethoxazole (P &lt; .01), ciprofloxacin (P &lt; .001), and nitrofurantoin (P &lt; .001). All isolates were susceptible to imipenem. ESBL-producing K pneumoniae may also be resistant to non-beta-lactam antibiotics. Therefore, susceptibility testing of these isolates is critical for guiding therapy.

american journal of clinical pathology

Comparative Genomic Hybridization: Synchronous Occurrence of Focal Nodular Hyperplasia and Hepatocellular Carcinoma in the Same Liver Is Not Based on Common Chromosomal Aberrations