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Ischemic stroke remains a major health problem associated with high mortality and severe morbidity. The challenge of treatment is to understand the process leading to endogenous neurorepair mechanism to ischemic stroke. This study tested the hypothesis that VSEL, SDF-1 and BDNF have important roles in the process endogenous neurorepair in response to ischemic stroke. Studies indicated an increase in SDF-1 and VSEL within one week of stroke. BDNF levels tapered after day 15. Together the studies indicated that BDNF levels were highest when measured within 7 days of stroke onset and decreased thereafter. SDF-1 and VSEL were highest at between 7 and 15 days of stroke onset. The findings indicated that SDF-1 could be key for VSEL to be mobilized as a natural repair process whereas BDNF might be the correlative response to prevent cell death.

international journal of translational science

Levels of Stromal Derived Factor-1 (SDF-1) and Brain Derived Neurotropic Factor (BDNF) and Very Small Embryonic-Like Cells (VSEL) in Ischemic Stroke Patients