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(3g/day) for 3 weeks to prevent the feline urolithiasis syndrome (FUS). To examine the toxicity of methionine against cats, 3 healthy cats were administered orally with 2g of DL-methionine daily for 20 days. As a result, many erythrocytes containing large Heinz bodies appeared in the peripheral blood of all the cats at 15 days. At 18 days, the concentration of methionine in the plasma and erythrocytes of the cats reached 9-13 mM (control; 29ƒÊM) and 6 mM (control; 39ƒÊM), respectively. The methemoglobin concentration also increased to 8-29% (control; 2%). Polychromato-

Methionine-Induced Hemolytic Anemia with Methemoglobinemia and Heinz Body Formation in Erythrocytes in Cats