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Background: Intrauterine devices (IUDs) are good contraceptive method for women as they have a long acting contraceptive effect compared to other hormonal methods. Misoprostol or prostaglandin El (PGE1) analogue is a synthetic prostaglandin that has been used to induce cervical ripening in vaginal delivery and in medical induction of abortion. Objective: To investigate the possible effect of vaginal administration of misoprostol to insertion of IUCDs in women with previous IUCD insertion failure. Subjects and methods: This study was done at Obstetrics and Gynecology Department of at El-Hussien hospital. It is a double blind randomized clinical trial. The study included 100 patients with previous failed attempt of IUD insertion, divided into two equal groups: Group I received misoprostol prior to IUD insertion and group II received placebo to IUD insertion. Results: There was high significant difference between the two groups regarding the degree of cervical softening and its effect on the success rate of IUCD insertion in each group. Conclusion: Vaginal misoprostol before IUD insertion in parous women with previous insertion failure increased the rate of successful insertion, particularly in women with previous cesarean delivery.

USING OF MISOPROSTOL VAGINALLY PRIOR TO INTRAUTERINE CONTRACEPTIVE DEVICE INSERTION FOLLOWING PREVIOUS INSERTION FAILURE: RANDOMIZED CLINICAL TRIAL