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Background: Platelets are important mediators of coagulation, inflammation, and atherosclerosis. We conducted a large population study with National Health and Nutrition Examination Survey (NHANES) data to understand the relationship of total platelet count (TPC) with health and disease in humans. Methods: NHANES is a cross-sectional survey of non-institutionalized United States adults, administered every 2 years by the Centers for Disease Control and Prevention. Participants answer a questionnaire, receive a physical examination, and undergo laboratory tests. TPC values were analyzed for a six-year period of NHANES (2011–2016). Weighted 10th and 90th percentiles were calculated, and logistic regression was used to predict likelihood (Odds ratio [OR]) of being in categories with TPC 90th percentile. Statistical analysis was performed using Stata/SE 15.1, using population weights for complex survey design. Results: The mean TPC for our sample (N = 17,969) was 236 × 103/μL (SD = 59 × 103) with the 10th percentile 170 × 103/μL and the 90th percentile 311 × 103/μL. Hispanics (other than Mexican Americans) and obese individuals had lower odds of a TPC 90th percentile. Individuals with a congestive heart failure (CHF) or coronary heart disease (CHD) diagnosis had over twice the odds (OR 2.06, 95% CI: 1.50-2.82, p = 90th percentile (OR 1.84, 95% CI: 1.08-3.13, p = 0.026, and 1.25, 95% CI: 1.00-1.56, p = 0.046, respectively). A diagnosis of chronic obstructive pulmonary disease and cancer did not have significant associations with TPC. Conclusions: Our study showed that obese individuals are more likely to have higher TPC. Individuals with CHF and CHD had higher odds of having TPC 90th percentile.

the southwest respiratory and critical care chronicles

Significance of platelet counts in health and disease: Insights from a population study using data from the National Health and Nutrition Examination Survey