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Functionalised magnetic nanoparticles composed of Fe3O4 particles stabilised by sodium oleate and subsequently modified with dextran (MFDEX) were prepared by the co-precipitation method Their morphology and particle size distribution were observed by scanning electron microscopy and photon c ross correlation spectroscopy In order to confirm the modification of magnetite surface with dextran physical techniques, including infrared spectroscopy, thermal analysis, and magnetic measurement, were used Finally, the effect of MFDEX on amyloid fibrillar aggregates of human insulin and hen egg white lysozyme, typical amyloidogenic proteins, was investigated In vitro interaction of MFDEX with protein amyloid fibrils resulted into destruction of amyloid aggregates The anti-amyloid activity makes MFDEX of potential interest as therapeutic agent against amyloid-related diseases

acta physica polonica. a

Characterization of Fe<sub>3</sub>O<sub>4</sub>Magnetic Nanoparticles Modified with Dextran and Investigation of Their Interaction with Protein Amyloid Aggregates

Characterization of Fe3O4Magnetic Nanoparticles Modified with Dextran and Investigation of Their Interaction with Protein Amyloid Aggregates

Characterization of Fe₃O₄Magnetic Nanoparticles Modified with Dextran and Investigation of Their Interaction with Protein Amyloid Aggregates