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Despite tremendous efforts, a large cadre of excellent researchers have been unable to definitively identify any cause of interstitial cystitis/bladder pain syndrome (IC/BPS) or develop more effective treatments. Newer research suggests that IC/BPS may have an infectious etiology. IC/BPS may also be related to mast cells, which have not been re-evaluated adequately. Many of the new investigative techniques, such as DNA/genomic analysis, microbiomes, and mycobiomes, applied from the fields of microbiology, infectious diseases, gastroenterology and mast cell specialists, have not have been fully utilized and applied to the field of urology and the study IC/BPS. Additional collaboration with these other fields of medicine may have a substantial impact on IC/BPS research and will likely move the urology community much closer to the causes of, and possible cures for, this most debilitating disease.

Interstitial cystitis/bladder pain syndrome research: the answer may be just around the corner