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      Background : Lead (Pb) exposure even at a low dose can induce functional and structural impairments in both humans and experimental animals. The present study evaluated the potential ameliorative role of pomegranate juice (PJ), as a powerful antioxidant fruit against histopathological and ultrastructural changes caused by Pb in the retina of pregnant rats and their neonates.    Methods:  24 pregnant female rats were selected and randomly divided into four groups (n=6): control, PJ supplemented (100 μL PJ), Pb treated (18.5 mg / kg B.Wt), and Pb co-supplemented alternatively with PJ group. After birth, the mother rats, as well as their neonates at different ages (7, 14, and 21 days old), were dissected and the eyes were removed for histological, ultrastructural, and immunohistochemical investigation of the retina.     Results:  The obtained results revealed deleterious histological and ultrastructural lesions in all retinal cell layers of Pb-treated female rats and their offspring. Such lesions included hypertrophied cells of retinal pigmented epithelium (RPE) with pronounced vacuolated mitochondria and fragmented Bruch's membrane. The outer and inner segments of photoreceptors appeared fragmented and detached from the RPE. Additionally, the outer nuclear layer (ONL) and inner nuclear layer (INL) appeared disorganized with vacuolated cytoplasm and pyknotic nuclei. The immunohistochemical results displayed glial fibrillary acidic protein (GFAP) weak expression and P53 strong expression in the retinal sections of the Pb-treated group of female rats and their neonates if compared with control.    Conclusions:  PJ successfully alleviated the deleterious histological and ultrastructural as well as immunohistochemical changes induced by lead.

Evaluation of lead toxicity on the retina of pregnant rats and their pups: the possible ameliorative role of pomegranate juice