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Background:  Ultraviolet B (UVB) radiation induces physiological and morphological photoaging of the skin resulting in wrinkles, and loss of elasticity. This study analyzed nanoencapsulation of a gel combination of  Centella asiatica  (CA) transfersomes and rosemary essential oil (REO) nanoemulsion with lipid-based nanocarriers for the ability of both biological compounds to synergistically prevent UVB radiation, along with ameliorative and anti-aging effects.    Methods:  To ensure the quality, lipid-based nanocarriers of transfersomes and nanoemulsion were characterized based on physicochemical properties such as particle size distribution, polydispersity index, zeta potential.  In vivo  studies were used to determine the biological effects of a gel combination of CA transfersomes, and REO nanoemulsion applied topically two weeks before UVB radiation (840 mJ/cm 2 ) in BALB/c hairless mice.    Results:  Results showed that the optimum lipid-based nanocarriers had a particle size of 43.97 ± 5.6 nm, a polydispersity index of 0.64 ± 0.01, and a zeta potential of -10.91 ± 1.99 mV.  In vivo  experiments revealed that topical application of a gel combination of CA transfersomes and REO nanoemulsion significantly ameliorated wrinkle formation, epidermal hyperplasia, and collagen fiber arrangement caused by UVB exposure. Further, the gel combining CA transfersomes and REO nanoemulsion suppressed lipid peroxidation by decreasing the expression of malondialdehyde (MDA) and collagen destruction by inhibiting matrix metalloproteinase-9 (MMP-9) expression. Moreover, the gel combination of CA transfersomes and REO nanoemulsion upregulated type I collagen through activation of the transforming growth factor-β (TGF-β)/Smad pathway, thereby recovering the density of collagen fiber reduced by UVB radiation.    Conclusions:  Overall, these data indicate that topical application of a gel combination of CA transfersomes and REO nanoemulsion could act synergistically and potentially prevents oxidative stress and collagen degradation in the skin from UVB-induced photoaging.

f1000research

Ameliorative effect of gel combination of Centella asiatica extract transfersomes and rosemary essential oil nanoemulsion against UVB-induced skin aging in Balb/c mice