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The cerebrovascular permeability quantitatively determined by the retention of 131I-human albumin in the perfused brains was increased in SHR, especially in stroke-prone SHR compared with normotensive Wistar-Kyoto, and confirmed the macroscopical or microscopical findings on the leakage into the brain or trypan blue or peroxidase injected intravenously 2 to 3 hours before sacrifice. The localization of increased vascular permeability in SHR corresponded to the predilection sites of cerebral hemorrhage or softening, which developed likely following the increased cerebrovascular permeability.

japanese circulation journal

Experimental Studies on the Pathogenesis and Prophylaxis of Stroke in Stroke-prone Spontaneously Hypertensive Rats(SHR) : (1) Quantitative Estimation of Cerebrovascular Permeability