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This study compared the diagnostic value of myocardial perfusion imaging (MPI) between the rest-stress 99 m Tc-tetrofosmin protocol (Tc/Tc protocol) and simultaneous acquisition rest 99 m Tc-tetrofosmin/stress 201 Tl dual-isotope protocol (SDI protocol) with a semiconductor camera.Methods and Results: We retrospectively studied 147 patients who underwent stress MPI using a cadmium-zinc-telluride camera and invasive coronary angiography within a 3-month interval. The Tc/Tc and SDI protocols were used in 59 and 88 patients, respectively. The sensitivity, specificity, and accuracy of the summed difference score in per-patient analysis were 56%, 85%, and 69%, respectively, for the Tc/Tc protocol and 89%, 82%, and 85%, respectively, for the SDI protocol. The area under the receiver operating characteristic curve was significantly better for the SDI than Tc/Tc protocol for the left anterior descending artery (0.836 vs. 0.674; P=0.0380), the left circumflex artery (0.754 vs. 0.599; P=0.0441), and in per-patient analysis (0.875 vs. 0.707; P=0.0135). There was no significant difference in the diagnostic accuracy of the summed stress score for any vessel or in per-patient analysis between the 2 protocols.

circulation journal

Diagnostic Performance of the Simultaneous Acquisition Rest &lt;sup&gt;99 m&lt;/sup&gt;Tc-Tetrofosmin/Stress &lt;sup&gt;201&lt;/sup&gt;Tl Dual-Isotope Protocol With a Semiconductor Camera ― Comparison With the Rest-Stress &lt;sup&gt;99 m&lt;/sup&gt;Tc-Tetrofosmin Protocol ―