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platinum metal are completely different chemical compounds, having scarce common points in their chemical and biological properties. Moreover, the reference for the hypersensitivity reactions to taxanes seems to have little to do with the Absorb scaffold. Another important issue that Kounis et al have raised is the acidosis that is induced during the process of Absorb degradation. Although it is true that acidosis can have harmful effects on the local coronary vasculature, it is very unlikely that the lactic acid produced by Absorb degradation induces a significant acidic condition, based on the following data. 1. The average polymer weight of the largest size 3.5×28 mm Absorb is 18.8 mg, and the total amount of lactic acid generated from this scaffold is 23.5 mg (the molecular weight of PLA repeating unit is 72 Daltons and the molecular weight of lactic acid is 90 Daltons).

Where Are the Secrets of Increased Thrombosis and Aneurysm Formation With the Current Bioresorbable Vascular Scaffolds Hidden? ― Reply ―