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Berbamine, a natural compound from Barberry, was reported to protect myocardium from ischemia/reperfusion (I/R) injury, but the underlying mechanisms are largely unknown.

circulation journal

Berbamine Protects the Heart From Ischemia/Reperfusion Injury by Maintaining Cytosolic Ca&lt;sup&gt;2+&lt;/sup&gt; Homeostasis and Preventing Calpain Activation