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Sirolimus-eluting stents (SES) are widely used in coronary artery disease as revascularization therapy. Although endothelial dysfunction induced by implanted SES can become a major clinical concern, therapeutic strategies to overcome this disorder remain unclear. The aim of the present study was therefore to identify effective therapies in a clinically relevant animal model.

circulation journal

Candesartan With Pioglitazone Protects Against Endothelial Dysfunction and Inflammatory Responses in Porcine Coronary Arteries Implanted With Sirolimus-Eluting Stents