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Angiotensin II and insulin resistance (IR) have clinical implications in the pathophysiology of chronic heart failure (CHF). However, it is still unclear whether the combination of an angiotensin-receptor blocker and angiotensin-converting enzyme inhibitor (ACEI) improves IR in CHF patients who do not receive β-blockers. Thus, the aim of the present study was to evaluate the effects of losartan on glucose metabolism and inflammatory cytokines in CHF patients treated with ACEI but not β-blockers.

circulation journal

Addition of Losartan to Angiotensin-Converting Enzyme Inhibitors Improves Insulin Resistance in Patients With Chronic Heart Failure Treated Without .BETA.-Blockers