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The H19 imprinting control region (ICR), located on chromosome 11p15.5, has been reported hypomethylated in 20-65% of Silver-Russell syndrome (SRS) patients.

the journal of clinical endocrinology and metabolism/journal of clinical endocrinology and metabolism

Clinically Distinct Epigenetic Subgroups in Silver-Russell Syndrome: The Degree of<i>H19</i>Hypomethylation Associates with Phenotype Severity and Genital and Skeletal Anomalies

Clinically Distinct Epigenetic Subgroups in Silver-Russell Syndrome: The Degree ofH19Hypomethylation Associates with Phenotype Severity and Genital and Skeletal Anomalies