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The modulation of the purinergic receptor P2X7 may be implicated in human carcinogenesis. The 1513A&gt;C and 489C&gt;T polymorphisms of P2X7R gene induce loss of function and gain of function, respectively.

the journal of clinical endocrinology and metabolism/journal of clinical endocrinology and metabolism

1513A&amp;gt;C Polymorphism in the P2X7 Receptor Gene in Patients with Papillary Thyroid Cancer: Correlation with Histological Variants and Clinical Parameters