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We study the mechanism underlying the attraction between nucleosomes, thefundamental packaging units of DNA inside the chromatin complex. We introduce asimple model of the nucleosome, the eight-tail colloid, consisting of a chargedsphere with eight oppositely charged, flexible, grafted chains that representthe terminal histone tails. We demonstrate that our complexes are attracted viathe formation of chain bridges and that this attraction can be tuned bychanging the fraction of charged monomers on the tails. This suggests aphysical mechanism of chromatin compaction where the degree of DNA condensationcan be controlled via biochemical means, namely the acetylation anddeacetylation of lysines in the histone tails.

Controlled DNA compaction within chromatin: The tail-bridging effect