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Background Peptic ulcer is the term which refers to acid peptic injury of the digestive tract, and it results in mucosal break reaching the submucosa. Leaves of  Capparis zeylanica  are used as counterirritant, rubefacient, as a cataplasm in piles, boils and swellings. The objective of the present study was to evaluate the antiulcer activity of  C. zeylanica  ethanolic extract against chemically induced ulcers. The leaves were extracted with ethanol (50%) as solvent using hot perforation method. The extract was evaluated against acute and chronic ulcer models. Further, extract was evaluated for gastric autopsy of animals infected with  Helicobacter pylori  bacteria. The genes of rats were evaluated by gel electrophoresis method. Morphology of stomach was also studied after treatment with plant extract. Results Results exhibited that the area of ulcer was significantly reduced in both acute [naproxen-induced ulcer model (3.62 mm 2 ), histamine-induced ulcer model (3.2 mm 2 ) and ethanol-induced ulcer model (106.4 mm 2 )] and chronic [chronic naproxen-induced ulcer model (2.14 mm 2 ), chronic histamine-induced ulcer model (0.16 mm 2 )]. The animals of naproxen-induced ulcer infected with  H. pylori  showed 91.48% reduction of ulcer area on 9th week after treatment with  C. zeylanica  extract (360 mg/kg). The rapid urease test and DNA observation revealed that no infection was present from 4th week after treatment with  C. zeylanica  extract (480 mg/kg). Morphological studies showed less conspicuous petechial marks and hemorrhages in stomach tissues after treatment with test drugs. Histopathological study revealed that  C. zeylanica  extract reduced stomach damages and eradicated  H. pylori  infections. Conclusion It can be concluded from the study that  C. zeylanica  possess antiulcer and anti-helicobacter activities.

Antiulcer activity of ethanolic leaf extract of Capparis zeylanica against chemically induced ulcers