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Background Our purpose was to evaluate the application of volumetric histogram parameters obtained from conventional MRI and apparent diffusion coefficient (ADC) images for grading the meningioma tumors. Results Tumor volumetric histograms of preoperative MRI images from 45 patients with the diagnosis of meningioma at different grades were analyzed to find the histogram parameters. Kruskal-Wallis statistical test was used for comparison between the parameters obtained from different grades. Multi-parametric regression analysis was used to find the model and parameters with high predictive value for the classification of meningioma. Mode; standard deviation on post-contrast T1WI, T2-FLAIR, and ADC images; kurtosis on post-contrast T1WI and T2-FLAIR images; mean and several percentile values on ADC; and post-contrast T1WI images showed significant differences among different tumor grades (P &lt; 0.05). The multi-parametric linear regression showed that the ADC histogram parameters model had a higher predictive value, with cutoff values of 0.212 (sensitivity = 79.6%, specificity = 84.3%) and 0.180 (sensitivity = 70.9%, specificity = 80.8%) for differentiating the grade I from II, and grade II from III, respectively. Conclusions The multi-parametric model of volumetric histogram parameters in some of the conventional MRI series (i.e., post-contrast T1WI and T2-FLAIR images) along with the ADC images are appropriate for predicting the meningioma tumors’ grade.

Grading of meningioma tumors based on analyzing tumor volumetric histograms obtained from conventional MRI and apparent diffusion coefficient images