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Objective  This study aimed at investigating the association between the rs7903146 (C/T) polymorphism of the  TCF7L2  gene with obesity in a Cameroonian population.    Method  This was a case-control pilot study including 61 obese and 61 non-obese Cameroonian adults. Anthropometric indices of obesity, blood pressure, fasting blood glucose, and blood lipids were measured. The rs7903146 (C/T) polymorphism of the  TCF7L2  gene was genotyped using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), and genotypes were correlated with clinical and biological parameters.    Results  The T allele was predominant in the study population with a frequency of 93%. No statistically significant difference was however observed between the genotypic ( p  = 0.50) and allelic frequencies ( p  = 0.58) of obese and non-obese subjects. Comparison of clinical and biochemical parameters of C allele carriers (CX = CC + CT) with those of TT genotype showed that there was no significant difference between the lipid profile of these two groups.    Conclusion  The rs7903146 (C/T) polymorphism of the  TCF7L2  gene might not be associated with obesity in the Cameroonian population.

Investigation of the association between the TCF7L2 rs7903146 (C/T) gene polymorphism and obesity in a Cameroonian population: a pilot study