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Zymomonas mobilis  is a well-recognized ethanologenic bacterium with outstanding characteristics which make it a promising platform for the biotechnological production of relevant building blocks and fine chemicals compounds. In the last years, research has been focused on the physiological, genetic, and metabolic engineering strategies aiming at expanding  Z. mobilis  ability to metabolize lignocellulosic substrates toward biofuel production. With the expansion of the  Z. mobilis  molecular and computational modeling toolbox, the potential of this bacterium as a cell factory has been thoroughly explored. The number of genomic, transcriptomic, proteomic, and fluxomic data that is becoming available for this bacterium has increased. For this reason, in the forthcoming years, systems biology is expected to continue driving the improvement of  Z. mobilis  for current and emergent biotechnological applications. While the existing molecular toolbox allowed the creation of stable  Z. mobilis  strains with improved traits for pinpointed biotechnological applications, the development of new and more flexible tools is crucial to boost the engineering capabilities of this bacterium. Novel genetic toolkits based on the CRISPR-Cas9 system and recombineering have been recently used for the metabolic engineering of  Z. mobilis . However, they are mostly at the proof-of-concept stage and need to be further improved. Graphical Abstract

Zymomonas mobilis as an emerging biotechnological chassis for the production of industrially relevant compounds