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BackgroundIn general, high-quality seed is the prerequisite of an efficient bioprocess. However, in terms of sodium gluconate production by Aspergillus niger, reports have seldom focused on seed culture with rational optimization by process analysis technology, especially for carbon source effects. In this study, based on the online physiological parameter of oxygen uptake rate (OUR), and intracellular metabolite profiling, as well as cell morphology analysis, the effects of different initial glucose concentrations on seed culture by A. niger were investigated.

Influence of initial glucose concentration on seed culture of sodium gluconate production by Aspergillus niger