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Background  Body positioning affects the configuration and dynamic properties of the chest wall and therefore may influence decisions made to increase or decrease ventilating pressures and tidal volume. We hypothesized that unlike global functional residual capacity (FRC), component sector gas volumes and their corresponding regional tidal expansions would vary markedly in the setting of unilateral pleural effusion (PLEF), owing to shifting distributions of aeration and collapse as posture changed.    Methods  Six deeply anesthetized swine underwent tracheostomy, thoracostomy, and experimental PLEF with 10 mL/kg of radiopaque isotonic fluid randomly instilled into either pleural space. Animals were ventilated at V T  = 10 mL/kg, frequency = 15 bpm, I/E = 1:2, PEEP = 1 cmH 2 O, and FiO 2  = 0.5. Quantitative lung computed tomographic (CT) analysis of regional aeration and global FRC measurements by nitrogen wash-in/wash-out technique was performed in each of these randomly applied positions: semi-Fowler’s (inclined 30° from horizontal in the sagittal plane); prone, supine, and lateral positions with dependent PLEF and non-dependent PLEF.    Results  No significant differences in total FRC were observed among the horizontal positions, either at baseline ( p  = 0.9037) or with PLEF ( p  = 0.58). However, component sector total gas volumes in each phase of the tidal cycle were different within all studied positions with and without PLEF ( p  = < .01). Compared to other positions, prone and lateral positions with non-dependent PLEF had more homogenous V T  distributions among quadrants ( p  = .051). Supine position was associated with most dependent collapse and greatest tendency for tidal recruitment (48 vs ~ 22%,  p  = 0.0073).    Conclusions  Changes in body position in the setting of effusion-caused chest asymmetry markedly affected the internal distributions of gas volume, collapse, ventilation, and tidal recruitment, even though global FRC measurements provided little indication of these potentially important positional changes.    Electronic supplementary material  The online version of this article (10.1186/s40635-018-0175-4) contains supplementary material, which is available to authorized users.

intensive care medicine experimental

Positional effects on the distributions of ventilation and end-expiratory gas volume in the asymmetric chest—a quantitative lung computed tomographic analysis