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Background  Systematic review guidance recommends the use of programme theory to inform considerations of  if  and  how  healthcare interventions may work differently across socio-economic status (SES) groups. This study aimed to address the lack of detail on  how  reviewers operationalise this in practice.    Methods  A methodological systematic review was undertaken to assess if, how and the extent to which systematic reviewers operationalise the guidance on the use of programme theory in considerations of socio-economic inequalities in health. Multiple databases were searched from January 2013 to May 2016. Studies were included if they were systematic reviews assessing the effectiveness of an intervention and included data on SES. Two reviewers independently screened all studies, undertook quality assessment and extracted data. A narrative approach to synthesis was adopted.    Results  A total of 37 systematic reviews were included, 10 of which were explicit in the use of terminology for ‘programme theory’. Twenty-nine studies used programme theory to inform both their a priori assumptions and explain their review findings. Of these, 22 incorporated considerations of both  what  and  how  interventions do/do not work in SES groups to both predict and explain their review findings. Thirteen studies acknowledged 24 unique theoretical references to support their assumptions of what or how interventions may have different effects in SES groups. Most reviewers used supplementary evidence to support their considerations of differential effectiveness. The majority of authors outlined a programme theory in the “Introduction” and “Discussion” sections of the review to inform their assumptions or provide explanations of  what  or  how  interventions may result in differential effects within or across SES groups. About a third of reviews used programme theory to inform the review analysis and/or synthesis. Few authors used programme theory to inform their inclusion criteria, data extraction or quality assessment. Twenty-one studies tested their a priori programme theory.    Conclusions  The use of programme theory to inform considerations of  if ,  what  and  how  interventions lead to differential effects on health in different SES groups in the systematic review process is not yet widely adopted, is used implicitly, is often fragmented and is not implemented in a systematic way.    Electronic supplementary material  The online version of this article (10.1186/s13643-017-0638-9) contains supplementary material, which is available to authorized users.

systematic reviews

Use of programme theory to understand the differential effects of interventions across socio-economic groups in systematic reviews—a systematic methodology review