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Background  In this pooled 2-center series LINAC radiosurgery (SRS) has been applied as a treatment option for a subset of refractory trigeminal neuralgia (TN) patients. This study approached to retrospectively assess the efficacy and safety of LINAC SRS and to provide a brief overview addressed to the technical development from frame-based towards frameless robotic SRS.    Methods  From 2001 to 2017  n  = 55 patients (pts) were treated,  n  = 28 were female (51%), mean age: 66 years (range 36–93 years); TN etiology: 37 classic TN, 15 multiple sclerosis (MS)-related TN, 2 symptomatic TN, and 1 atypical TN. Previous treatment was present in  n  = 35 (63.6%) pts. (some multiple or combined) with  n  = 23 microsurgical vascular decompression and  n  = 17 percutaneous retrogasserian rhizotomy. A 6 MV LINAC (4–5 mm collimators) was applied in all pts. ( n  = 26 framebased -  n  = 29 frameless robotic). The dorsal root entry zone (DREZ) was targeted in n = 35 cases and the retrogasserian target in  n  = 20 pts. with a homogeneous dose for the entire study cohort (90 Gy). SRS outcome was measured using the Barrow Neurological Institute (BNI) score for pain and hypaesthesia and statistically evaluated by univariate and multivariate analyzes.    Results  Mean follow-up (FU) was 30 months (2 lost FU); the total rate of post SRS BNI pain I-IIIa (=painfree w or w/o medication) was 69% (88% for the classic TN pts), 29% (38.8% classic TN) were classified as BNI pain I-II (=painfree w/o medication). A BNI hypaesthesia II-III was present in 9.4% ( n  = 5) and BNI hypaesthesia IV in  n  = 2. Between groups analysis demonstrated no correlation of SRS responsiveness with age, gender, MS- or not MS-associated TN, previous surgery, framebased/frameless robotic SRS. DREZ targeting significantly better suppressed TN compared to RG targeting ( p  = 0.01). Additionally, a statistical trend for a better BNI pain outcome ( p  = 0.07) along with a significant increase in BNI hypaesthesia ( p  = 0.01) was found when using a larger partial trigeminal 70 Gy volume.    Conclusion  Our retrospective analysis support LINAC SRS as an effective and safe treatment option in TN. Frameless robotic SRS of TN is safe when using a dedicated LINAC system. A target definition closer to the brainstem and tendencially a larger target volume were associated with a better outcome for pain.

LINAC stereotactic radiosurgery for trigeminal neuralgia –retrospective two-institutional examination of treatment outcomes