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Background  Rapid and sensitive detection of H 2 O 2  especially endogenous H 2 O 2  is of great importance for series of industries including disease diagnosis and therapy. In this work, uniform FePt nanoparticles are successfully anchored onto Few-layer molybdenum disulfide nanosheets (F-MoS 2  NSs). The powder X-ray diffraction, transmission electron microscopy, UV–Vis spectra and atomic force microscopy were employed to confirm the structure of the obtained nanocomposites (F-MoS 2 -FePt NCs). The prepared nanocomposites show efficient peroxidase-like catalytic activities verified by catalyzing the peroxidation substrate 4,4′-diamino-3,3′,5,5′-tetramethylbiphenyl (TMB) with the existence of H 2 O 2 .    Results  The optimal conditions of the constructed colorimetric sensing platform is proved as 35 °C and pH 4.2. Under optimal catalytic conditions, the detection limit for H 2 O 2  detection reaches 2.24 μM and the linear ranger is 8 μM to 300 μM. Furthermore, the proposed colorimetric sensing platform was successfully utilized to detect the intracellular H 2 O 2  of cancer cells (MCF-7).    Conclusions  These findings indicated that the F-MoS 2 -FePt-TMB-H 2 O 2  system provides a potential sensing platform for hydrogen peroxide monitoring in living cells.    Electronic supplementary material  The online version of this article (10.1186/s12951-019-0465-3) contains supplementary material, which is available to authorized users.

journal of nanobiotechnology

A facile preparation of FePt-loaded few-layer MoS2 nanosheets nanocomposites (F-MoS2-FePt NCs) and their application for colorimetric detection of H2O2 in living cells