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Background  Meratrim is a blend of two plant extracts obtained from  Sphaeranthus indicus  flower heads and  Garcinia mangostana  fruit rinds. Previous studies have demonstrated that Meratrim is effective for weight management in obese individuals. The objective of this study was to assess the efficacy and tolerability of Meratrim in managing body weight in healthy overweight subjects.    Methods  Sixty participants with a mean BMI of 28.3 kg/m 2  were randomized into two groups receiving either 400 mg of Meratrim twice daily or two identical placebo capsules for a period of 16 weeks. Subjects were asked to consume about 2,000 kcal/day throughout the study period and walk 5 days a week for 30 min daily. The primary endpoint was defined as the change in body weight from baseline to end of week 16 for the Meratrim group versus placebo. Fifty seven subjects completed the trial.    Results  At study conclusion, statistically significant reductions in body weight (5.09 vs. 1.1 kg;  p  < 0.0001), BMI (1.91 vs. 0.43 kg/m 2 ;  p  < 0.0001), waist (9.97 vs. 3.71 cm;  p  < 0.001) and hip size (10.38 vs. 5.11 cm;  p  < 0.0001) were observed in the Meratrim versus the placebo group. Additionally, a significant change in serum LDL (−14.79 vs. 6.25 mg/dL;  p  < 0.0001), triglycerides (−43.62 vs. -13.68 mg/dL;  p  < 0.001) and total cholesterol (−20.0 vs. -0.75 mg/dL;  p  = 0.0002) was observed in the Meratrim cohort compared to the placebo. No supplementation related adverse events were noted during the study.    Conclusions  The study findings suggest that Meratrim is well-tolerated and is an effective ingredient for weight management in healthy overweight subjects.    Trial registration  CTRI/2014/07/004727;  www.CTRI.nic.in

Efficacy and tolerability of Meratrim for weight management: a randomized, double-blind, placebo-controlled study in healthy overweight human subjects