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The methylation of N 6  adenosine (m 6 A) plays a critical role in diverse biological processes. However, knowledge regarding the reconstitution of m 6 A across cancer types is still lacking. Here, we systematically analyzed the molecular alterations and clinical relevance of m 6 A regulators across > 10,000 subjects representing 33 cancer types. We found that there are widespread genetic alterations to m 6 A regulators, and that their expression levels are significantly correlated with the activity of cancer hallmark-related pathways. Moreover, m 6 A regulators were found to be potentially useful for prognostic stratification, and we identified IGF2BP3 as a potential oncogene across multiple cancer types. Our results provide a valuable resource that will guide both mechanistic and therapeutic analyses of the role of m 6 A regulators in cancer.   Supplementary information   Supplementary information  accompanies this paper at 10.1186/s12943-019-1066-3.

Molecular characterization and clinical relevance of m6A regulators across 33 cancer types