English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background  Long noncoding RNAs (lncRNAs) are important regulators in tumor progression. However, their biological functions and underlying mechanisms in hypoxia adaptation remain largely unclear.    Results  Here, we established a correlation between a Chr3q29-derived lncRNA gene and tongue squamous carcinoma (TSCC) by genome-wide analyses. Using RACE, we determined that two novel variants of this lncRNA gene are generated in TSCC, namely  LINC00887_TSCC_short  ( 887S ) and  LINC00887_TSCC_long  ( 887L ). RNA-sequencing in  887S  or  887L  loss-of-function cells identified their common downstream target as  Carbonic Anhydrase IX  ( CA9 ), a gene known to be upregulated by hypoxia during tumor progression. Mechanistically, our results showed that the hypoxia-augmented  887S  and constitutively expressed  887L  functioned in opposite directions on tumor progression through the common target  CA9 . Upon normoxia,  887S  and  887L  interacted. Upon hypoxia, the two variants were separated. Each RNA recognized and bound to their responsive DNA cis-acting elements on  CA9  promoter:  887L  activated  CA9 ’s transcription through recruiting HIF1α, while  887S  suppressed  CA9  through DNMT1-mediated DNA methylation.    Conclusions  We provided hypoxia-permitted functions of two antagonistic lncRNA variants to fine control the hypoxia adaptation through CA9.    Supplementary Information  The online version contains supplementary material available at 10.1186/s12915-021-01112-2.

bmc biology

A pair of long intergenic non-coding RNA LINC00887 variants act antagonistically to control Carbonic Anhydrase IX transcription upon hypoxia in tongue squamous carcinoma progression