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Background  In the present study, the methanol extracts from the leaves, as well as compounds namely sigmoidin I ( 1 ), atalantoflavone ( 2 ), bidwillon A ( 3 ), neocyclomorusin ( 4 ), 6α-hydroxyphaseollidin ( 5 ) and neobavaisoflavone ( 6 ) (from the bark extract) were tested for their activities against a panel of Gram-negative bacteria including multi-drug resistant (MDR) phenotypes.    Methods  Broth microdilution method was used to determine the minimum inhibitory concentrations (MICs) and the minimum bactericidal concentrations (MBCs) of the extracts as well as compounds  1 – 6 .    Results  The MIC results indicated that the crude extracts from the leaves and bark of this plant were able to inhibit the growth of 96.3 % of the 27 tested bacteria. Compounds  2 – 6  displayed selective activities, their inhibitory effects being obtained on 8.3 %, 41.7 %, 58.3 %, 58.3 % and 66.7 % of tested bacteria respectively for  2 ,  3 ,  5 ,  6  and  4 . The lowest MIC value of 8 μg/mL was obtained with  6  against  Escherichia coli  ATCC8739,  Enterobacter cloacae  ECCI69,  Klebsiella pneumoniae  KP55,  Providencia stuartii  NAE16 and  Pseudomonas aeruginosa  PA01.    Conclusion  The present study demonstrates that  Erythrina sigmoidea  is a potential source of antibacterial drugs to fight against MDR bacteria. Neobavaisoflavone ( 6 ) is the main antibacterial consituents of the bark crude extract.

Antibacterial activities of the methanol extracts and compounds from Erythrina sigmoidea against Gram-negative multi-drug resistant phenotypes