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Background  To assess the effect of a 12-day treatment using a vaginal gel based on niosomes containing hyaluronic acid, ß-glucan, alpha-glucan oligosaccharide,  Coriolus versicolor ,  Asian centella ,  Azadirachta indica  and  Aloe vera  on vaginal microbiota, cervical epithelization and vaginal health.    Methods  Open-label, prospective pilot study conducted in asymptomatic women in daily practice. Cervical epithelization was evaluated by colposcopy using an ectopy epithelization score (from 5: no ectopy to 1: severe ectopy and bleeding), vaginal microbiota using the VaginaStatus-Diagnostic test (Instiüt für Mikroökologie, Herborn, Germany) and further rated by the investigator using a 5-point Liker scale (from 5: normal to 1: very severe deterioration in which all evaluated species were altered), and vaginal health using the Vaginal Health Index.    Results  In 21 women, a positive effect to improve epithelization of the cervical mucosa, with a mean score of 4.42 at the final visit as compared to 3.09 at baseline ( P  < 0.0001) (43% improvement). In 10 women, there was a trend of improving of vaginal microbiota status, with a mean score of 4.0 at the final visit vs. 3.3 at baseline ( P  = NS) (21.2% improvement). In 11 women, the Vaginal Health Index increased from 19.0 at baseline to 22.3 at the final visit ( P  = 0.007). The concentration of  Lactobacillus  spp. increased 54.5% of women and pH decreased from 4.32 to 4.09.    Conclusions  These encouraging preliminary results provide the basis for designing a randomized controlled study, and for potential use in human papilloma virus infection.    Trial registration    ISRCTN77955077 . Registration date: February 15, 2017. Retrospectively registered

bmc women's health

Beneficial effects of a Coriolus versicolor-based vaginal gel on cervical epithelization, vaginal microbiota and vaginal health: a pilot study in asymptomatic women