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Background  Hypertension is the leading risk factor for cardiovascular disease (CVD), however, the studies on lifestyle and genetic risks in Chinese pilgrims to Hajj was limited. The aim of this study is to examine the prevalence and associated lifestyle and genetic risks for hypertension among Hui Hajj pilgrims in China.    Methods  We performed a cross-sectional analysis of data in 1,465 participants aged 30–70 years who participated in a medical examination for Hui  Hajj  pilgrims from Gansu province, China in 2017. Multiple logistic regression was used to evaluate the association of potential risk factors with hypertension. Deoxyribonucleic acid (DNA) polymorphism was examined at sites in the renin-angiotensin-aldosterone system ( RAAS ).    Results  The prevalence of hypertension was 47% among this population. Lifestyle factors such as fried food preference (like vs. dislike: odds ratio [OR]: =1.53, 95% confidence interval [CI]: 1.13–2.09) and barbecued food preference (like vs. dislike: OR = 1.45, 95% CI: 1.06–1.97) were associated with elevated risk of hypertension among Hui pilgrims. Comparing with Angiotensin converting enzyme ( ACE ) rs4425  AA  genotype,  TT  genotype was associated with hypertension risk (OR = 2.16, 95% CI: 1.17–4.00). Similar results were also observed for  ACE  rs4437  CC  genotype (OR = 1.95, 95% CI: 1.07–3.55), Angiotensin II receptor ( ATR ) rs129876  AA  genotype (OR = 4.10, 95% CI: 2.30–7.32) and Aldosterone synthase ( CYP11B2 ) rs1912  TT  genotype (OR = 2.82, 95% CI: 1.57–5.06) genotypes.    Conclusions  Unhealthy lifestyle and genetic factors were associated with the prevalence of hypertension in Chinese Hui pilgrims and their interactions were also observed.    Electronic supplementary material  The online version of this article (10.1186/s12889-019-7357-1) contains supplementary material, which is available to authorized users.

bmc public health

A cross-sectional study on factors associated with hypertension and genetic polymorphisms of renin-angiotensin-aldosterone system in Chinese hui pilgrims to hajj