English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Background  Induction therapy can improve kidney transplantation (KTx) outcomes, but little is known about the mechanisms underlying its effects.    Methods  The mRNA levels of T cell-related genes associated with tolerance or rejection ( CD247, GZMB, PRF1, FOXP3, MAN1A1, TCAIM,  and  TLR5 ) and lymphocyte subpopulations were monitored prospectively in the peripheral blood of 60 kidney transplant recipients before and 7, 14, 21, 28, 60, 90 days, 6 months, and 12 months after KTx. Patients were treated with calcineurin inhibitor-based triple immunosuppression and induction with rabbit anti-thymocyte globulin (rATG,  n  = 24), basiliximab ( n  = 17), or without induction (no-induction,  n  = 19). A generalized linear mixed model with gamma distribution for repeated measures, adjusted for rejection, recipient/donor age and delayed graft function, was used for statistical analysis.    Results  rATG treatment caused an intense reduction in all T cell type population and natural killer (NK) cells within 7 days, then a slow increase and repopulation was observed. This was also noticed in the expression levels of  CD247 ,  FOXP3 ,  GZMB , and  PRF1.  The basiliximab group exhibited higher  CD247 ,  GZMB ,  FOXP3  and  TCAIM  mRNA levels and regulatory T cell (Treg) counts than the no-induction group. The levels of  MAN1A1  and  TLR5  mRNA expressions were increased, whereas  TCAIM  decreased in the rATG group as compared with those in the no-induction group.    Conclusion  The rATG induction therapy was associated with decreased T and NK cell-related transcript levels and with upregulation of two rejection-associated transcripts ( MAN1A1  and  TLR5 ) shortly after KTx .  Basiliximab treatment was associated with increased absolute number of Treg cells, and increased level of  FOXP3  and  TCAIM  expression.

Effect of induction therapy on the expression of molecular markers associated with rejection and tolerance