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Background  Quantitative bone SPECT/CT is useful for disease follow up and inter-patient comparison. For bone metastatic malignant lesions, spine is the most commonly invaded site. However, Quantitative studies with large sample size investigating all the segments of normal cervical, thoracic and lumbar vertebrae are seldom reported. This study was to evaluate the quantitative tomography of normal vertebrae using  99m Tc-MDP with SPECT/CT to investigate the feasibility of standardized uptake value (SUV) for differential diagnosis of benign and malignant bone lesions.    Methods  A retrospective study was carried out involving 221 patients (116 males and 105 females) who underwent SPECT/CT scan using  99m Tc-MDP. The maximum SUV (SUV max ), mean SUV (SUV mean ) and CT values (Hounsfield Unit, HU) of 2416 normal vertebrae bodies, 157 benign bone lesions and 118 malignant bone metastasis foci were obtained. The correlations between SUV max  of normal vertebrae and CT values of normal vertebrae, age, height, weight, BMI of patients were analyzed. Statistical analysis was performed with data of normal, benign and malignant groups corresponding to same sites and gender.    Results  The SUV max  and SUV mean  of normal vertebrae in males were markedly higher than those in females ( P  < 0.0009). The SUV max  of each normal vertebral segment showed a strong negative correlation with CT values in both males and females (r = − 0.89 and − 0.92, respectively;  P  < 0.0009). The SUV max  of normal vertebrae also showed significant correlation with weight, height, and BMI in males (r = 0.4,  P  < 0.0009; r = 0.28,  P  = 0.005; r = 0.22,  P  = 0.026), and significant correlation with weight and BMI in females (r = 0.32,  P  = 0.009; r = 0.23,  P  = 0.031). The SUV max  of normal group, benign bone lesion group and malignant bone metastasis foci group showed statistical differences in both males and females.    Conclusion  Our study evaluated SUV max  and SUV mean  of normal vertebrae, benign bone lesion and malignant bone metastasis foci with a large sample population. Preliminary results proved the potential value of SUV max  in differentiation benign and malignant bone lesions. The results may provide a quantitative reference for clinical diagnosis and the evaluation of therapeutic response in vertebral lesions.    Supplementary Information  The online version contains supplementary material available at 10.1186/s12880-021-00569-5.

bmc medical imaging

Standardized uptake values of 99mTc-MDP in normal vertebrae assessed using quantitative SPECT/CT for differentiation diagnosis of benign and malignant bone lesions