English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Aim  This study has conducted a comparative analysis of common carbapenemases harboring, the expression of resistance-nodulation-cell division (RND) family efflux pumps, and biofilm formation potential associated with carbapenem resistance among  Acinetobacter baumannii (A. baumannii ) strains with different carbapenem susceptibility. Methods: A total of 90 isolates of  A. baumannii  from two tertiary hospitals of China were identified and grouped as carbapenem susceptible  A. baumannii  (CSAB) strains and carbapenem non-susceptible  A. baumannii  (CnSAB) strains based on the susceptibility to imipenem. Harboring of carbapenemase genes, relative expression of RND family efflux pumps and biofilm formation potential were compared between the two groups. Result: Among these strains, 12 (13.3 %) strains were divided into the CSAB group, and 78 (86.7 %) strains into the CnSAB group. Compared with CSAB strains, CnSAB strains increased distribution of  bla  OXA−23  ( p  < 0.001) and IS Aba1 / bla  OXA−51−like  ( p  = 0.034) carbapenemase genes, and a 6.1-fold relative expression of  adeB  ( p =  0.002), while CSAB strains led to biofilm formation by 1.3-fold than CnSAB strains ( p  = 0.021).    Conclusions  Clinically, harboring more  bla  OXA−23−like  and IS Aba1/bla  OXA−51−like  complex genes and overproduction of adeABC are relevant with carbapenem resistance, while carbapenem susceptible strains might survive the stress of antibiotic through their ability of higher biofilm formation.

bmc infectious diseases

Comparative analysis of carbapenemases, RND family efflux pumps and biofilm formation potential among Acinetobacter baumannii strains with different carbapenem susceptibility