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Background  The gastric microbiota has recently been implicated in the causation of organic/structural gastroduodenal diseases (gastric and duodenal ulcers, gastric cancer) in patients with  Helicobacter pylori (H. pylori)  infection. We aimed to ascertain, in patients harbouring  H. pylori , the role of the gastric microbiota in the causation of symptoms (chronic dyspepsia) in the absence of organic disease.    Methods  Seventy-four gastric biopsy samples obtained at endoscopy from patients with ( n  = 21) or without ( n  = 53) chronic dyspepsia, and that tested positive by the bedside rapid urease test for  H. pylori  infection, were cultured for detection of  H. pylori  and non- H. pylori  organisms. The cultured organisms were identified by matrix-assisted laser desorption ionization time-of-flight mass spectroscopy (MALDI-TOF MS).    Results  A total of 106 non- H. pylori  isolates were obtained from 74 patients’ samples. This included 33 isolates (median 2, range 1–2 per patient) from dyspeptic and 73 (median 2, range 1–2 per patient) from non-dyspeptic patients. These were identified from the Bruker Biotyper 2 database as Staphylococcus spp., Streptococcus spp., Lactobacillus spp., Micrococcus spp., Enterococcus spp., Pseudomonas spp., Escherichia spp., Klebsiella spp. and Bacillus spp., Staphylococcus and Lactobacillus were identified significantly more commonly in dyspeptics and Streptococcus, Pseudomonas,  Escherichia coli  and  Klebsiella pneumoniae  in non-dyspeptics. All identified organisms belonged to the phyla Firmicutes and Proteobacteria.    Conclusions  There is a qualitative difference in the gastric microbial spectrum between patients harbouring  H. pylori  with and without chronic dyspepsia. Whether these organisms have an independent role in the development or prevention of dyspepsia or act in concurrence with  H. pylori  needs study.

bmc gastroenterology

Gastric bacterial Flora in patients Harbouring Helicobacter pylori with or without chronic dyspepsia: analysis with matrix-assisted laser desorption ionization time-of-flight mass spectroscopy