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Background    Helicobacter pylori  ( H. pylori ) infection and eradication therapy have been known to influence gastric ghrelin and leptin secretion, which may lead to weight gain. However, the exact relationship between plasma ghrelin/leptin levels and  H. pylori  infection has remained controversial. The aim of this study was to investigate plasma ghrelin and leptin levels in  H. pylori -positive and -negative patients, to compare the two levels of the hormones before and after  H. pylori  eradication, and to examine the correlation between body mass index (BMI) and active ghrelin or leptin levels, as well as that between atrophic pattern and active ghrelin or leptin levels.    Methods  Seventy-two  H. pylori -positive patients who underwent upper gastrointestinal endoscopy, 46 diagnosed as having peptic ulcer and 26 as atrophic gastritis, were enrolled. Control samples were obtained from 15 healthy  H. pylori -negative volunteers. The extent of atrophic change of the gastric mucosa was assessed endoscopically. Body weight was measured and blood was collected before and 12 weeks after  H. pylori  eradication therapy. Blood samples were taken between 8 and 10 AM after an overnight fast.    Results  Plasma ghrelin levels were significantly lower in  H. pylori -positive patients than in  H. pylori -negative patients. In particular, plasma active ghrelin levels were significantly lower in patients with gastritis compared with patients with peptic ulcer. Plasma ghrelin levels decreased after  H. pylori  eradication in both peptic ulcer and gastritis patients, while plasma leptin levels increased only in peptic ulcer patients. Plasma leptin levels and BMI were positively correlated, and active ghrelin levels and atrophic pattern were weakly negatively correlated in peptic ulcer patients.    Conclusion    H. pylori  infection and eradication therapy may affect circulating ghrelin/leptin levels. This finding suggests a relationship between gastric mucosal injury induced by  H. pylori  infection and changes in plasma ghrelin and leptin levels.

Changes in plasma ghrelin and leptin levels in patients with peptic ulcer and gastritis following eradication of Helicobacter pylori infection