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Background  Fresh gas decoupling is a feature of the modern anesthesia workstation, where the fresh gas flow (FGF) is diverted into the reservoir bag and is not added to the delivered tidal volume, which thus remains constant. The present study aimed to investigate the entraining of the atmospheric air into the anesthesia breathing circuit in case the reservoir bag was disconnected.    Methods  We conducted a simulator-based study, where the METI HPS simulator was connected to the anesthesia workstation. The effect of the disconnected reservoir bag was evaluated using oxygen (O 2 ) and air or oxygen and nitrous oxide (N 2 O) as a carrier gas at different FGF rates. We disconnected the reservoir bag for 10 min during the maintenance phase. We recorded values for inspiratory O 2 , N 2 O, and sevoflurane. The time constant of the exponential process was estimated during reservoir bag disconnection.    Results  The difference of O 2 , N 2 O and sevoflurane concentrations, before, during, and after reservoir bag disconnection was statistically significant at 0.5, 1, and 2 L/min of FGF ( p  < 0.001). The largest decrease of the inspired O 2  concentrations (F I O 2 ) was detected in the case of oxygen and air as the carrier gas and an FGF of 1 L/min, when oxygen decreased from median [25th–75th percentile] 55.00% [54.00–56.00] to median 39.50% [38.00–42.50] ( p  < 0.001). The time constant for F I O 2  during reservoir bag disconnection in oxygen and air as the carrier gas, were median 2.5, 2.5, and 1.5 min in FGF of 0.5, 1.0, and 2 L/min respectively.    Conclusions  During the disconnection of the anesthesia reservoir bag, the process of pharmacokinetics takes place faster compared to the wash-in and wash-out pharmacokinetic properties in the circle breathing system. The time constant was affected by the FGF rate, as well as the gradient of anesthetic gases between the anesthesia circle system and atmospheric air.

Effects of the reservoir bag disconnection on inspired gases during general anesthesia: a simulator-based study