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Background  Hemolysins are crucial virulence factors which help pathogens to survive and persist in the host. This study investigated whether common electrolytes will affect the hemolysins of  Candida  species. The hemolysins from 25  Candida  isolates were investigated using a plate specially designed for  Candida  species in the presence of three electrolytes, CaCl 2 , NaCl and KCl, at different concentrations. The hemolytic activity was determined after 48 h and the hemolytic index was calculated.    Results  All three electrolytes caused a decrease in the hemolytic activity. Significant differences existed between varying concentrations of NaCl, while no significant differences existed for the CaCl 2  and KCl groups. Additionally, the peripheral hemolytic index was highly correlated with the hemolytic index ( r  = 0.656,  p  < 0.001).    Conclusions  Our findings indicate that electrolytes reduce hemolysis by  Candida  species and a correlation exists between the peripheral hemolytic index and the translucent hemolytic index.

Changes in the hemolytic activity of Candida species by common electrolytes