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Background  Actinomycetes are Gram-positive, often filamentous, bacteria known for their unsurpassed capacity for the production of secondary metabolites with diverse biological activities. The aim of the present study was to evaluate the antimicrobial, cytotoxic and antioxidant properties of  Streptomyces lavendulae  strain SCA5.    Results  The ethyl acetate extract of SCA5 broth (EA-SCA5) showed antimicrobial activity with MIC value of 31.25 μg/ml. EA-SCA5 showed good antioxidant potential by scavenging 2, 2-diphenyl-picrylhydrazyl (DPPH) (IC 50  507.61 ± 0.66 μg/ml), hydroxyl radical (IC 50  617.84 ± 0.57 μg/ml), nitric oxide (IC 50  730.92 ± 0.81 μg/ml) and superoxide anion radical (IC 50  864.71 ± 1.15 μg/ml). The EA-SCA5 also showed strong suppressive effect on rat liver lipid peroxidation (IC 50  838.83 ± 1.18 μg/ml). The total phenolic content of SCA5 was 577.12 mg of GAE equivalents/gram extract. EA-SCA5 exhibited cytotoxic activity on A549 adenocarcinoma lung cancer cell line. It showed 84.9% activity at 500 μg/ml with IC 50  value of 200 μg/ml. The gas chromatography mass spectrometry (GC-MS) analysis revealed the presence of one major bioactive compound actinomycin C2.    Conclusions  The results of this study indicate that the EA-SCA5 could be probed further for isolating some medically useful compounds.    Electronic supplementary material  The online version of this article (doi:10.1186/s12866-014-0291-6) contains supplementary material, which is available to authorized users.

In vitro antimicrobial, antioxidant and cytotoxic properties of Streptomyces lavendulae strain SCA5