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Background  Antibodies against Region III-V of the erythrocyte binding antigen (EBA) 175 (EBA175RIII-V) have been suggested to provide protection from malaria in a natural infection. However, the quality and quantity of naturally induced antibodies to EBA175RIII-V has not been fully characterized in different cohorts of Ghanaians. This study sought to determine the characteristics of antibodies against EBA175RIII-V in asymptomatic adults and children living in two communities of varying  P. falciparum  parasite prevalence in southern Ghana.    Methods  Microscopic evaluation of thick and thin blood smears was used to identify asymptomatic  Plasmodium falciparum  carriage and indirect enzyme linked immunosorbent (ELISA) used to assess antibody concentrations and avidity.    Results  Parasite carriage estimated by microscopy in Obom was 35.6% as opposed to 3.5% in Asutsuare. Levels of IgG, IgG1, IgG2, IgG3 and IgG4 against EBA175RIII-V in the participants from Obom were significantly higher ( P  < 0.05, Dunn’s Multiple Comparison test) than those in Asutsuare. However the relative avidity of IgG antibodies against EBA175RIII-V was significantly higher ( P  < 0.0001, Mann Whitney test) in Asutsuare than in Obom.    Conclusions  People living in communities with limited exposure to  P. falciparum  parasites have low quantities of high avidity antibodies against EBA175RIII-V whilst people living in communities with high exposure to the parasites have high quantities of age-dependent but low avidity antibodies against EBA175RIII-V.    Electronic supplementary material  The online version of this article (10.1186/s12865-018-0271-y) contains supplementary material, which is available to authorized users.

bmc immunology

Characterization of anti-EBA175RIII-V in asymptomatic adults and children living in communities in the Greater Accra Region of Ghana with varying malaria transmission intensities