English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Zendy Plus

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Zendy Tools

Zendy Open

Background  In this study, we retrospectively analyzed the relationship between headache recurrence and serotonin 5-HT 1B/1D  receptor occupancy (Φ 1B  and Φ 1D ). Triptans marketed in Japan (sumatriptan, zolmitriptan, eletriptan, rizatriptan, naratriptan) were investigated.    Methods  Receptor occupancies were calculated from both the pharmacokinetic and pharmacodynamic data of triptans. We examined the relationships between recurrence rate and elimination half-lives, and Ф 1B  and Ф 1D , as calculated from the time-course of plasma drug concentration obtained from other studies. The time until Ф 1B  and Ф 1D  became 50 % or less, 40 % or less, and 30 % or less was calculated as duration time to examine the relationship with recurrence rate.    Results  For Ф 1B , eletriptan remained at a low level. For Ф 1D , it was indicated that all triptans obtained an occupancy of 80 % or higher at maximum. For all items, though recurrence tended to be lower along with longer half-life, no significant statistical correlation was found. For both Ф 1B  and Ф 1D , the recurrence rate tended to be lower as the duration became longer. In addition, a significant correlation was observed for Ф 1D  (p < 0.05). For clarifying the Ф value and time period most closely correlated with recurrence rate, recurrence and Ф 1B  and Ф 1D  at 6, 12, and 18 h after administration were calculated. The most significant correlation was observed between recurrence rate and Ф 1D  at 12 h after administration (p < 0.01).    Conclusions  As an index for evaluating headache recurrence following triptan administration, recurrence rate and Ф 1D  value at 12 h after administration were found to be most closely correlated and useful for analysis. Our results indicate that headache recurrence inhibition can be evaluated using these values.

Theoretical analysis of headache recurrence in patients administered triptans for migraine based on receptor occupancy