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We want to point out that G-CSF use in premenopausal node-positive breast cancer patients, especially in the era of induced angiogenesis may activate and repopulate these dormant breast cancer stem cells more efficently besides its stimulation on blood stem cells. Consequently, activated breast cancer stem cells become chemosensitive to cell-cycle specific various chemotherapeutic agents.

breast cancer research

Addition of granulocyte-colony stimulating factor (G-CSF) may further increase chemosensitive state in premenopausal node-positive breast cancer patients with induced angiogenesis after surgery