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Mutations in known predisposition genes account for only about a third of all multiple-case breast cancer families. We hypothesized that germline mutations in FANCD2, BRIP1/BACH1, LMO4 and SFN may account for some of the unexplained multiple-case breast cancer families.

Mutation analysis of FANCD2, BRIP1/BACH1, LMO4 and SFN in familial breast cancer