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Dexmedetomidine is a potent and selective alpha-2 agonist, and is widely used for not only an adjunct to anesthesia but also sedation during mechanical ventilation in intensive care unit. It has been reported that, although the substance does not appear to have any direct effects on the myocardial contractility, it sometimes causes a decrease in heart rate and a dose-dependent decrease in arterial blood pressure and, in rare cases, leads to cardiac arrest or shock. However, detailed mechanisms remain uncertain. We hypothesized that effects of dexmedetomidine to coronary vasoactivity and cardiac function may differ depending on postnatal ages.

1110. Age-related effects of dexmedetomidine, an alpha-2 agonist, on coronary vasoactivity and cardiac function in guinea-pig hearts